They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...

Tau is a microtubule-associated protein encoded by the MAPT gene located on chromosome 17q21. It promotes microtubule assembly and stability and may play a role in establishing and maintaining ...

Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...

The team reported that the treatment has significantly cleared tau protein build-up and enhanced cognitive functioning among mice with neurodegenerative diseases. So, according to the researchers ...

Trimming Alzheimer's-linked proteins This new technique for targeting tau tangles utilizes a 2010 discovery from Dr. Leo ...

Using zebrafish and mice, scientists from the University of Cambridge have shown that a common glaucoma drug might be able to protect the brain from the buildup of tau protein, which has been ...

Increased levels of tau and the ... β and tau proteins); Neuropeptides may contribute to the enhancement of neuronal survival and functional recovery after TBI by inducing Akt activation and ...

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is ...

Rather than knocking down or overexpressing TMEM106b as other mouse studies have done, Rothstein and colleagues wanted to investigate how the endogenous protein responded in the setting of TDP-43 or ...