Excitatory synapses are located in confined chemical spaces called the dendritic spines. These are atypical femtoliter-order microdomains where the behavior of even single molecules may have ...

"I'm honored, humbled and excited to continue our research on synapse biology in the context of Alzheimer's disease with these two new NIH grants," he said. "With Alzheimer's disease on the rise ...

When naive T cells encounter antigen-presenting cells (APCs), membrane and cytoplasmic molecules rearrange at the T cell–APC contact area to form the immune synapse. Finetti et al. now reveal an ...

An electrical impulse cannot directly cross the gap so a different mechanism has to be used. Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ...

However, a series of weak stimuli can combine, increasing the amount of neurotransmitter that is released. This results in enough neurotransmitter being diffused across the synaptic cleft to ...