在一项新的研究中，来自巴塞罗那基因组调控中心的研究人员首次绘制了人类剪接体（spliceosome）的蓝图，其中这种剪接体是每个人体细胞内部最复杂、最错综复杂的分子机器。相关研究结果发表在2024年11月1日的 Science 期刊上，论文标题为 ...

When a cell requires a protein, it generates a copy of the relevant instructions in the cell nucleus. During splicing, this ...

Is this a glimpse of the spliceosome's catalytic core? Identifying divalent metal ion binding sites in RNA molecules is a formidable task, especially when the RNAs reside within large, dynamic ...

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome ...

New work suggests that Prp8, a highly conserved protein in the heart of the spliceosome, both orients the substrate and participates in catalysis. The U5 snRNP functions in spliceosome assembly as ...

During splicing, this transcript undergoes modification: a cellular editing complex, the spliceosome, removes certain segments. The outcome varies depending on which parts are cut out, resulting ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona, a BIST Community centre, have created the first blueprint of the human spliceosome, the most complex and intricate molecular ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

USP39 stabilizes the spliceosome (green), which cuts out unneeded parts (grey and purple) of the mRNA. If USP39 is missing, some of the mRNA is poorly processed. This results in misfolded proteins ...

We study regulation of gene expression by the minor spliceosome. This parallel pre-mRNA splicing machinery functions during the nuclear RNA processing phase and regulates cellular mRNA levels. We ...