The binding of AMP to AMPK and activation of its Ser/Thr protein-kinase domain have been well-characterized by previous biochemical and genetic analyses. Two studies now shed light on the ...
By exploring the conservation and functional diversity of RIPK3 and related RHIM-containing proteins across vertebrates, this important work sheds light on the e ...
WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and ...