WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and ...
A research group of The University of Tokyo has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study ...
Glycogen synthase kinase 3 (GSK3 ... and contributes to the stimulation of glycogen and protein synthesis. Figure 4: The molecular mechanism by which phosphorylation inhibits GSK3.
The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling ... This insight from simulation suggests SEN as a mechanism for limiting the ...