The NMR and Drug Metabolism Core has developed rapid and efficient approaches to investigate metabolism, metabolic stability, pharmacokinetics (PK), and chemical structure identification of small ...

The quantitative aspects of drug absorption, distribution, metabolism, and excretion will be explored. The philosophy of pharmacokinetic modeling and its application in practice will be introduced. An ...

Pharmacokinetics is an area of pharmacology concerned with the time course of absorption, distribution, metabolism and excretion (collectively ADME) of drugs from biological systems in order to ...

The pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories at three dosage strengths and oral syrup were studied. The study had an open-label, randomized ...

Urinary aMT6s levels are negligible in this gestational age group, probably because of immature liver metabolism. This melatonin PK data will be used in future clinical studies to test the ...

Janne Backman, leads research on pharmacokinetics, drug-drug interactions and the molecular mechanisms causing them. Recent research has focused on drug-drug interactions caused by irreversible ...

A possible explanation is differences in first-pass metabolism among individual subjects. Some of the variability after rectal administration may be related to the site of absorption within the ...

A body weight-adjusted regimen of Uptravi dosing for children and adolescents with PAH was deemed appropriate, according to a ...