Genetic and biochemical data are assimilated to arrive at a current picture of UV-damage-induced mutagenesis. An unprecedented DNA polymerase V transactivation mechanism, which involves the RecA ...

The mutations that occur in the brain mostly seem to occur when the cells are expressing their genes.” Neurons don’t divide, and most of the time their DNA is tightly bundled and protected from damage ...

This DNA has suffered a mutation, either through mis-copying (when its parent cell divided), or through the damaging effects of exposure to radiation or a chemical carcinogen.

albeit at the risk of incorporating mutations. This process not only enables bacteria to survive acute DNA damage but also supports mutagenesis under antibiotic stress, contributing to resistance ...

As previously mentioned, one important DNA damage response (DDR ... however (Sinha & Hader, 2002). Mutations in an organism's DNA are a part of life. Our genetic code is exposed to a variety ...

Within the framework of a DFG-funded Collaborative Research Centre (Transregio 353 "Regulation of cell death decisions"), a research team from the University of Konstanz has now shown that different ...

Discover the pivotal role of extrachromosomal DNA (ecDNA) in cancer biology and its implications for future treatments.

When cell growth gets out of control and malignant cells begin to proliferate, cancer can develop in a process known as ...

have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of ...

Cancer cells experience more DNA damage than healthy cells due to their rapid division, making them especially reliant on repair mechanisms. When these repair systems are compromised—either through ...

Tel Aviv University's study reveals critical insights into autism caused by SHANK3 mutations and demonstrates successful ...