A retrospective chart review was performed on 145 adult ... patients who received only one dose of metronidazole, and patients who received oral metronidazole only. The 145 patients were in ...

Severe hepatic impairment (Child-Pugh C): reduce metronidazole dose by 50%. No dose adjustment needed for mild to moderate hepatic impairment, but monitor for metronidazole associated adverse events.

The precise mechanism of action of metronidazole is unclear. Infuse over 1hr. Anaerobic infections: 15mg/kg (loading dose), then 7.5mg/kg every 6hrs for 7–10 days; max 4g/24hrs. Bone/joint ...