We have also recently demonstrated that the adenosine nucleotide translocase (ANT) proteins are integral components of the mitochondrial permeability transition pore (MPTP). We have found that ...
Here, MPTP administration is accompanied by the ... are affected by disease-related abnormalities such as inflammation, mitochondrial dysfunction, oxidative stress, or misfolding and aggregation ...
Creatine, in the form of phosphocreatine, a high-energy phosphate, buffers cellular ATP and prevents opening of the mitochondrial permeability transition pore. Creatine attenuates MPP+-mediated ...
Mitochondrial Proteomic Studies on Toxin-based Animal Models of PD As discussed, several chemicals that induce aspects of human PD in animals predominantly act by impairing mitochondrial function ...