During rolling, leukocytes receive signals from the inflamed vessel wall, which induce a further slowing down and eventual firm arrest (adhesion) of the leukocyte to the vessel wall. Firm ...

Currently, the group focuses on: The regulation of integrin activity by phosphorylation The role of integrins and the intercellular adhesion molecule ICAM-5 in the central nervous system Effect of ...

Leukocyte Adhesion Deficiency-I (LAD-I), a severe pediatric genetic disorder that causes recurrent and life-threatening infections which are frequently fatal, and Pyruvate Kinase Deficiency (PKD ...

Both agents reduced leukocyte adhesion to the endothelium by almost 50% in affected mice, compared with controls. Notably, rapamycin also reduced leukocyte infiltration of the mucosa, whereas ...

We are interested in leukocyte beta2-integrins, important cell surface receptors in leukocytes which regulate both adhesion and signalling in immune cells. Support scientific breakthroughs – become a ...