Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...
Initially, T cell engineering depended on lentiviral or retroviral vectors to deliver DNA fragments into a cell for homologous recombination ... directed repair mechanisms, CRISPR editing can ...
The precise insertion of DNA sequences using the homology-directed repair (HDR) pathway is one potential use of the CRISPR/Cas genome editing technology. Various circumstances could influence the ...
The CRISPR molecular scissors have the potential to revolutionize the treatment ... Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements. Commun Biol.
The CRISPR molecular scissors have the potential ... Unfortunately, however, there is a catch: under certain conditions, the repair can lead to new genetic defects—as in the case of chronic ...
CRISPR-based gene-editing tools are being developed to correct specific defective sections of the genome to cure inherited genetic diseases, with some applications already in clinical trials. However, ...