Initially, T cell engineering depended on lentiviral or retroviral vectors to deliver DNA fragments into a cell for homologous recombination ... directed repair mechanisms, CRISPR editing can ...
The CRISPR molecular scissors have the potential ... Unfortunately, however, there is a catch: under certain conditions, the repair can lead to new genetic defects—as in the case of chronic ...
The CRISPR molecular scissors have the potential to revolutionize the treatment ... Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements. Commun Biol.
CRISPR-based gene-editing tools are being developed to correct specific defective sections of the genome to cure inherited genetic diseases, with some applications already in clinical trials. However, ...