Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Unlike its DNA repair role in somatic cells, homologous recombination has a distinct role in meiosis in ensuring proper chromosome segregation. In yeast, an early step of the meiotic program is the ...

In four of six cases, the recombination resulting in the duplication occurred between homologous chromosomes (interchromosomal). In one duplication patient (1353), the duplication was derived from ...

In their recent Review article, Barzel and Kupiec 1 analyse some important issues concerning how homologous DNA sequences pair to facilitate homologous recombination (HR). However, the models ...

DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to ...

TOP1 is the target of topotecan, which was approved in 1997 by the U.S. Food and Drug Administration (FDA) to treat relapsed ...

Myriad Genetics, Inc. MYGN recently announced updates to its agreement with Illumina Inc. ILMN. The company’s gold-standard Genomic Instability Score (“GIS”) to determine Homologous Recombination ...

Hangzhou Synrx Therapeutics Biomedical Technology Co. Ltd. recently presented the development and characterization of a novel PARG inhibitor, SYN-608, for the potential treatment of tumors ...