The Hedgehog (Hh) pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. The first and often genetically ...

Each displayed differing tissue specificities, which suggests that the pathway functions differently in different cell types. Although all four inhibited hedgehog signaling in fibroblasts ...

Several components of the hedgehog (Hh) pathway are crucial to basal cell ... Phosphatase and tensin homolog function is critical for Hh signaling in embryonic development and in Hh-dependent ...

The trial outcomes for ENV-101 demonstrated statistically significant improvements in lung function and lung capacity.

The Phase IIb ‘Wound-remodeling Hedgehog-Inhibitor ILD Study Testing Lung Function Endpoints-PF ... address this gap by targeting the Hedgehog pathway, which is implicated in the abnormal ...