引言在生命科学的领域，DNA曾被誉为生命的“天书”，承载了生物体所有的遗传信息。然而，如何解读这本“天书”，从中提取关键的生物学信息，一直是科学界面临的巨大挑战。从基因表达到增强子活性，再到与疾病相关的遗传变异，这些复杂的分子表型背后隐藏着大量的规律 ...

The global nucleotide market size has an estimated market valuation of USD 672.5 Million by 2024 and is projected to grow at ...

Base substitutions are the simplest type of gene-level mutation, and they involve the swapping of one nucleotide for another during DNA replication. For example, during replication, a thymine ...

An international research collaboration has shed new light on the molecular basis of gene expression, the fundamental ...

Genomic sequencing Genomic sequencing is the process by which the sequence of nucleotide bases is determined for individual genes or even entire genomes.

In the end, the researchers were left with a mixture of newly synthesized DNA strands that differed in length by a single nucleotide, and that were labeled at their 3′ end with the color of the ...

Basic steps of genetic engineering. In step 1, a gene of interest consisting of a finite sequence of nucleotides synthesized one nucleotide at a time resulting in a double-stranded DNA linear sequence ...

Researchers used mitochondrial gene editing to model genetic disorders in mice, revealing profound impacts on brain function, ...

Mitochondrial DNA depletion syndrome (MTDPS) is a rare genetic disorder characterized by a marked decrease in mitochondrial ...

Mitochondrial diseases are among the most prevalent hereditary metabolic disorders, known to occur in 1 out of every 5,000 ...

For example, DNA methylation modifies gene expression without altering the nucleotide sequence. A well-studied DNA methylation-based phenomenon is genomic imprinting (ie, genotype-independent ...