This technique, called cryo-EM, enabled the researchers to solve the structure of TAS2R14 together with flufenamic acid (FFA)—a bitter anti-inflammatory drug that activates TAS2R14. The ...
Here, the authors report a cryo-EM structure of the human TAS2R14 in complex with its signaling partner gustducin, and bound to an anti-inflammatory drug flufenamic acid (FFA).