Crystal structures of a mammalian multidrug efflux pump bound to peptide inhibitors may reveal drug-binding sites. Figure 1: Ribbon renditions of the structure of P-glycoprotein embedded in a ...

The company’s pipeline includes investigational, preclinical and clinical stage anti-resistance agents based on novel mechanisms of action that include efflux pump inhibition and modulation of ...

Essays Biochem. 2021 Dec 17;65(6):857-866. PubMed ID: 34061186. Research on assembling and working mechanisms of multidrug efflux pump from bacteria is the most enduring project in my research, ...

Even when antimicrobials gain access via porins, they are frequently pumped back out of the cell by efflux pumps. Again, the cell can control which pumps are produced and under which circumstances.