Transient lower esophageal sphincter relaxation inhibitors such as GABA type B agonists and mGluR5 inhibitors have been shown to decrease GERD episodes and improve reflux-related symptoms.

Persisting acid or nonacid reflux ... classes of compounds are GABA type B agonists and metabotropic glutamate receptor 5 antagonists, which can reduce both reflux episodes and symptoms, but ...