these culminated in the International Knockout Mouse Consortium (IKMC) in 2007 with the aim to establish knockout and conditional mouse strains for all mouse genes. This article traces the origins ...

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

My laboratory studied the functions of neurotrophic factors in development and their relevance to neurodegenerative disease using a blend of transgenic mouse technology and anatomical, cell biological ...