long-range gene interactions and the complex network of trans-acting factors in the transmission of chromatin states. We first describe two examples of heritable transcription regulation from two ...

New research from the Center for Physical Genomics and Engineering uncovers how 3D genome structures generate cellular memories, paving the way for advances in medicine and longevity through cellular ...

Epigenetic modifiers, enzymes that catalyze covalent modifications on chromatin, play a pivotal role in establishing stable ...

This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

Chromatin is the physiological state of the genome. Approximately 50% of chromosomes and chromatin is protein. These include histones, transcription factors, nuclear receptors, co-activators, ...

Short-chain fatty acids influence gene regulation and chromatin accessibility, highlighting their role in colorectal cancer ...