The human immune system is a complex network of cells and signals that guards against disease, yet in the case of cancer, it ...

This study identifies SOX13 as the first γδ-lineage-specific transcription factor that seems to function as a switch to control γδ- versus αβ-T-cell development, in part, by controlling TCF1 ...

Co-expression of the inhibitory receptors PD-1 and CD73 regulates tolerance by restricting the expansion of auto-reactive CD4 + T cells independently of thymic selection. Pulendran and colleagues ...