The current gold standard therapy is the bisphosphonate class of antiresorptives, including alendronic acid (Fosamax/Bonalon; Merck), which inhibit osteoclast-mediated bone resorption. Another ...

They found that IL-3 is a powerful and irreversible inhibitor of TNF-induced bone resorption, even in the presence of other proinflammatory cytokines, such as IL-1α, transforming growth factor ...

In the adult skeleton, bone is in constant flux between resorption of old or damaged bone by osteoclasts and deposition of new bone by osteoblasts. The net balance between resorption and ...

OPG and RANKL Are Regulated by Systemic Hormones, Growth Factors, and Cytokines Cite this: Osteoprotegerin and its Ligand: A New Paradigm for Regulation of Osteoclastogenesis and Bone Resorption ...

1, RANK and NFATc1 expression during early stage of osteoclast differentiation (day 3) compared to TNF inhibitor or TNF inhibitor and OX40L inhibitor (n=3). Conclusion Our data suggested that IMB-101 ...