BRCA1 belongs to a family of tumor suppressor ... Specifically, these cells contained alterations in the structure and organization of chromatin, the material that helps package and maintain ...

The product of a sixth, newly-cloned FA-associated gene has been linked to BRCA1, and may finally offer some insight into the mechanism by which FA increases cancer susceptibility. You have full ...

The cells of the group with a single defective copy of the BRCA1 gene showed telltale changes in the organization and ...

In 1990, the first breast cancer susceptibility gene, BRCA1, was localized using linkage analysis to chromosome 17q21. [12] The following year, it was demonstrated that several ovarian cancer ...

A new study led by Harvard Medical School researchers shed new light on how even a single defective copy of the ...

Female carriers of germline BRCA1 mutations have a lifetime risk of breast cancer exceeding 80% and of ovarian cancer approaching 60%. The cumulative lifetime risk of developing either breast or ...

People inherit two copies of each gene — one from each parent — an evolutionary fail-safe to ensure survival even when one of ...

A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full ...