PD-1有两个结合配体,PD-L1(B7-H1或CD274)和PDL2(B7-DC或CD273)。PD-L1表达于活化的T细胞、B细胞、巨噬细胞、树突状细胞和癌细胞,PD-L2的表达有限,主要表达 ...
Duality Biologics Ltd. presented preclinical data on DB-1419, a potentially first-in-class bispecific antibody-drug conjugate (ADC) consisting of a humanized antibody targeting B7-H3 and PD-L1 ...