Every year, neurodegenerative diseases take a steep toll on millions of people, affecting individuals, their caregivers, families and communities. Most neurodegenerative diseases share a common ...

"In the early stages of several neurodegenerative diseases, autophagy is compromised, which means cells have a reduced repair capacity," Selleck said. "In this study, we determined that heparan ...

Mitophagy dynamics change with age, particularly during midlife, influencing brain health and aging. These findings offer ...

More information: Suhyun Kim et al, Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer's disease, Molecular Neurodegeneration (2024). DOI: 10.1186/s13024 ...

Denali Therapeutics' innovative approach to neurological disorders and strong financial strategy position it as a leader in ...

suggesting that impairment of the autophagy pathway regulation system could be one of the common bases of the two diseases; however, further studies are necessary, taking into account exposure to ...

Our interests include signal transduction, cilia, morphogenesis, cell death and autophagy, cytoskeleton, gene expression, cell division and polarity. Disease targets include cancer, cardiomyopathies, ...

New research from the McWilliams lab highlights middle age as a pivotal period for brain health, with significant changes in how cells remove damaged mitochondria. Defects in this recycling process ...

"We're looking at repositioning or repurposing tyrosine kinase inhibitors for neurodegenerative diseases, including Lewy body dementia," Turner said. "Due to its promotion of autophagy and perhaps ...