Kinases with a large range of substrates ... with the clathrin coat adaptor complex AP2 or by binding to other adaptor proteins, which in turn interacts with the clathrin heavy chain and/or ...

The research is published in the journal Nature Communications. During clathrin-mediated endocytosis, adaptor proteins bind to the cell membrane and to the protein clathrin, assisting in engulfing ...

Comprehending the significance of protein kinases in diseases such as cancer ... University uncover a groundbreaking inhibitor aimed at Adaptor Protein 2-Associated Protein Kinase 1 (AAK1).

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

By exploring the conservation and functional diversity of RIPK3 and related RHIM-containing proteins across vertebrates, this important work sheds light on the e ...

Our group focuses on two assembly pathways: adaptor protein assembly during vesicle budding and SNARE complex assembly during vesicle fusion. We aim to use findings from these two model pathways to ...

Sino Biological currently sells signaling enzymes, protein kinases, mutant kinases, lipid kinases, epigenetic enzymes, ubiquitination-related enzymes, and proteins associated with ...

2008;3(2):177-189. The bottom line is that the recognition of different Gram-negative and -positive microbes involves different TLR receptors and common adaptor proteins that create unique ...